Imipramine is a tricyclic antidepressant used in a number of conditions, ranging from depression to bedwetting. Outside of hospital settings it is usually administered by tablet. Treatment typically lasts 3 to 9 months, depending on the condition being treated, and in some cases can last considerably longer.

Imipramine is a generic name; it is known by a number of other names with slight variations that can be confusing, including imipramina, imipramin, imipraminum, and imipramine hydrochloride; these are all the same medication. Among brand names, patients most often buy imipramine as Tofranil or Antidep

This product should be used with caution in young and elderly patients. It should never be used in patients under age 6.

Psychiatric Applications

The majority of patients buy imipramine to treat depression, though it is sometimes used in other psychiatric disorders, including anxiety, ADHD, panic attacks, OCD, and others. Treatment is typically similar in these applications, though personal variables such as weight or other medications being taken may call for adjustments:

• Start with 75 mg per day, increased up to 200 mg per day after two weeks of treatment if 75 mg proves insufficient.
• Once symptoms are under control, a lower daily maintenance dose of 50 to 150 mg can be established.
• Patients should not exceed 200 mg per outside of hospital settings.
• Smaller doses may be taken once per day. Larger doses are often divided into 2, 3, or 4 smaller doses taken throughout the day.
• Treatment should not end abruptly, especially at higher doses. A doctor can help with a discontinuation plan that gradually reduces dosage.

Treatment typically lasts 6 to 9 months, though this can vary. Patients taking imipramine report:

• More stabilized mood
• Fewer and milder mood swings
• Improved focus and control of thoughts
• Less anxiety
• Increased energy

For psychiatric conditions imipramine is predominantly used in adults; adolescent patients should be treated only under the supervision of a professional.

Bedwetting & Night Terrors

The medication is used in children as young as 6 for nighttime bedwetting; less commonly parents buy imipramine to treat night terrors. In bedwetting, other causes, such as a physical problem, should be ruled out first.

Doses are typically considerably lower than those used in psychiatric patients, so there is less concern for side effects. Dosage should be determined by a doctor according the child's weight and typically starts with very low doses of 25 mg or less, increased in weekly increments, if needed, to a maximum dose of 2.5 mg per kg of body weight per day.

Tablets are typically administered about an hour prior to bed, though some have better results giving a half-dose in the afternoon and the other half before bed. Duration of treatment should be established by a doctor, and will likely last several months.

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